Development, Optimization, and evaluation of New herbal Antipsoriatic Emulgel

Objective: It is acknowledged that psoriasis is the most prevalent autoimmune condition brought on by the improper activation of the immune system. the lack of possible cure and associated severe side effects in allopathic medicines have led to extensive research in natural products with antipsoriatic activity. Bearing in mind this, and based on previous studies conducted at the Medicinal and Aromatic Plant and Traditional Medicine Research Institute (MAPTMRI), in which the activity of the Aloe sinkatan plant was proven as an effective treatment for psoriasis, it was selected to formulate, optimize and evaluate a new emulgel from Aloe sinkatana plant extract used as an anti-psoriatic agent. Method: The study included a multi-phase process that included the collecting and extraction of plants. Based on pre-formulation studies like solubility and compatibility studies, liquid paraffin, propylene glycol, Tween-۲۰ and Span-۲۰, alcohol, and DEMSO were selected for the forumaltion. The emulgels were designed, formulate and optimized using a ۲³ factorial design. Spreadability and viscosity were considered dependent variables, while the quantities of emulsifying agent, gelling agent and, liquid paraffin were chosen as independent formulation variables. Physical appearance and physiochemical parameters like stability, pH, viscosity, spreadability, and percentage medication content were evaluated for the produced formulations. Results: Regression analysis showed that all three independent variables significantly affected the response variables. The formulation was optimized using a response surface plot using Design Expert software ۸.۰.۷.۱. The R² values for the response's viscosity and spreadability were ۰.۹۹۱۵ and ۰.۹۷۶۱, respectively. Conclusion: Aloe sinkatana extract was used as an active component in the formulation of the emulgel form. Formula F۳ shows good physicochemical characteristics and a higher percent of drug content than other formulations; therefore, it was selected as an optimal formula.

کلیدواژه ها:

Keywords: Aloe sinkatana ، anti-psoriatic properties ، optimized formula ، emulgel formulation ، factorial analysis