Assessing Therapeutic Effects of Corn Starch Nanoparticles with Lavender Extract on Skin Wound Healing in Wistar Rats

Lavender has garnered interest because of its potential therapeutic effects. The objective of this research was to examine the healing properties of corn starch nanoparticles that contain lavender extract on skin wounds in Wistar rats. The scanning electron microscope, atomic force microscopy, and dynamic light scattering techniques were utilized. The analysis revealed that the nanoparticles have a diameter of around ۶۰ nm and exhibit a spherical morphology. Furthermore, a histological investigation was conducted by procuring tissue samples from the wound site on days ۳, ۷, ۱۴, and ۲۱ after the surgical procedure. Statistical studies were performed to ascertain the mean wound area, rate of wound healing, and percentage of wound healing among the different treatment groups. The data were analyzed using the TUKEY and Duncan multiple range tests in the SAS statistical software to discover statistically significant differences and evaluate intergroup variances across different time points. In addition, the group that received the ۵% nanoformulation treatment showed healing percentages of approximately ۶۰%, ۸۶%, and ۱۰۰% on the ۷th, ۱۴th, and ۲۱st days, respectively, as compared to the day the wounds were formed. The results indicate that maize starch nanoparticles containing lavender extract have beneficial and efficient capabilities for enhancing wound healing.

کلیدواژه ها:

corn starch ، lavender ، Linalyl acetate ، Nanoparticles ، Wistar rats ، wound healing