Association between menstrual disorders and anti-Müllerian hormone with COVID-۱۹: A prospective cohort study

Background: Coronavirus ۲۰۱۹ (COVID-۱۹) has affected almost all communities throughout the world. It affects different systems in the body, which causes irreparable consequences. Objective: This study aimed to investigate the effect of the COVID-۱۹ virus on menstrual disorders, anti-Mullerian hormone (AMH), thyroid peroxidase (TPO), thyroid stimulating hormone (TSH), and prolactin levels in women with COVID-۱۹ disease. Materials and Methods: This prospective cohort study was conducted on ۲۰۱ women (۱۰۱ healthy, and ۱۰۰ women with COVID-۱۹) in Nomadic hospital, Khorramabad, Iran from February-October ۲۰۲۱. After recovery from COVID-۱۹, participants were interviewed about their menstrual cycle in their ۱st and ۴th months. Blood samples were collected during ۱st and ۴th months, and AMH, TSH, TPO, and prolactin levels were assessed. Results: No significant differences were observed in the ۱st and ۴th months regarding menstrual disorders, TPO, and prolactin levels in the patient group (p > ۰.۰۵). The mean level of AMH in the healthy group was higher than the patient group in both times (p < ۰.۰۰۱). A relationship between TSH and COVID-۱۹ was observed in the ۱st month (p < ۰.۰۰۱); however, no significant relationship was observed in the ۴th month, in this regard. Conclusion: Endocrine dysfunction in the form of low AMH and high TSH were common among COVID-۱۹ patients. Due to the importance of menstrual and hormonal disorders, especially AMH and TSH, and their association with COVID-۱۹, health policymakers should find appropriate solutions to reduce complications.

کلیدواژه ها:

COVID-۱۹ ، AMH ، TSH ، TPO ، Prolactin ، Menstrual disorders. ، کووید-۱۹ ، آنتی­مولرین هورمون ، هورمون محرک تیروئید ، تیروئید پراکسیداز ، پرولاکتین ، اختلالات قاعدگی.