The Potential Role of hsa_circ_۰۰۰۴۲۱۴ as a Biomarker for Breast Cancer Prognosis

Breast cancer is the most important cause of cancer-related death among women. Finding cancer management biomarkers may improve cancer management strategies, patient outcomes, and quality of life. Recently circular RNA (circRNA) expression has attracted huge attention in cancer management. CircRNAs have a covalently closed loop structure that makes them resistant to exonuclease degradation and make them more stable than their linear counterparts. This study investigates the potential of hsa_circ_۰۰۰۴۲۱۴ as a circRNA derived from the angiomotin gene on chromosome ۱۱, as a candidate possible prognostic biomarker. SYBR Green real-time reverse transcription–polymerase chain reaction (RT-PCR) was used to assess the expression level of hsa_circ_۰۰۰۴۲۱۴ in ۴۰ breast ductal carcinoma tumors and whole blood samples from breast cancer patients, compared to the match control samples. The association between the expression levels of this circRNA and the clinical characteristics of breast cancer patients was assessed. The findings indicate that hsa_circ_۰۰۰۴۲۱۴ expression elevated in triple-negative cases and at higher stages of the disease (P< ۰.۰۵). The hsa_circ_۰۰۰۴۲۱۴ may proposed as a potential biomarker for breast cancer prognosis, with its elevated expression in advanced breast cancer situations proposing its utility in clinical settings. Further research is warranted to establish its prognostic value and potential implications in breast cancer management.

کلیدواژه ها:

Neoplasia ، circRNA ، Biomarker ، Breast cancer