One-pot four-component domino reaction for the synthesis of substituted dihydro-2-oxypyrrole catalyzed by ZrCl4

The synthesis of multi-functionalized dihydro-2-oxypyrrole can be achieved using one-pot four-component domino reaction from dialkylacetylenedicarboxylate, amines, and formaldehyde by employing ZrCl4 as catalyst at room temperature. The salient features of the present method are: simple,straightforward, cost-effective, environmentally benign, and no column chromatographic separation is applicable on broad range of substract.