The Impact of Combined Cranberry Supplementation and Weight Loss Diet on Inflammatory, Antioxidant, and Apoptosis Biomarkers in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized, Double-Blinded, Controlled Clinical Trial

Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease. The aim of this study is to evaluate the effect of combined weight loss diet and cranberry supplementation on anthropometric measurements, inflammation and antioxidant biomarkers in patients with NAFLD. Methods: In this randomized, double-blinded, and controlled clinical trial, ۴۱ NAFLD patients were supplemented with either cranberry or placebo tablets for ۱۲ weeks. Both groups followed a diet of ۵۰۰-۱۰۰۰ calories less than the estimated energy requirements. Serum levels of total antioxidant capacity (TAC), malondialdehyde (MDA), cytokeratin ۱۸ M۳۰ (CK-۱۸ M۳۰), chemokine C-C motif ligand ۲ (CCL۲) and tumor necrosis factor alpha (TNF-α) were measured at both baseline and the end of the study. Results: Significant improvements in TAC were observed in the cranberry group and between the two groups (P=۰.۰۰۶ and P=۰.۰۱۱, respectively), but the changes in the placebo group were not significant (P=۰.۳۲۵). There were no statistically significant differences in the serum levels of MDA, CK-۱۸ M۳۰, CCL۲ and TNF-α between the cranberry and the placebo groups (P>۰.۰۵).  Conclusions: It seems that daily consumption of cranberry supplement would be beneficial in increasing serum levels of TAC. Further studies are needed to investigate the effects of anti-inflammatory and antioxidant properties of cranberry on NAFLD.

کلیدواژه ها:

Vaccinium macrocarpon ، Non-alcohlic fatty liver diseases ، Inflammation ، Oxidative stress ، Apoptosis.