Fabrication and investigation of antibacterial properties of modified polyvinylalcohol nanofibers containing Mummy

Purpose: Polymer nanofibers are nanostructures with many applications in medical science.Electrospinning is a simple method to produce fibers with different thicknesses. Mumm is a drug withanti-inflammatory, antioxidant, and anti-cancer properties. Therefore, in this study, we synthesizednanofibers modified from PVA together with Mummy by electrospinning process, then weinvestigated their antibacterial properties.Method: First, the Mummy material was soaked. Then, nanofibers were prepared with PVA byelectrospinning method. The morphological and structural properties of nanofibers were analyzed byscanning microscope (SEM) and Fourier transform infrared spectrometer (FT-IR) techniques, andtheir antimicrobial properties against Pseudomonas aeruginosa and Staphylococcus aureus wereinvestigated.Results: The results of SEM analysis showed that nanofibers were prepared with an average diameterof ۳۲۹.۵ and ۴۴۴.۳ nm in the presence and absence of Mummy substance, respectively. The producednanofibers containing Mummy had inhibitory properties for both the bacteria used, but it had the mostantimicrobial properties against Gram-negative bacteria Pseudomonas aeruginosa.Conclusion: The results of this research showed that it is possible to load the Mummy substance onPVA nanofibers in order to produce an active substrate with antioxidant and antibacterial properties,and it improves the physical properties of nanofibers.

کلیدواژه ها:

Modified nanofibers ، electrospinning ، polyvinyl alcohol ، Mummy ، antibacterial