Inflammatory Biomarkers: The Hidden Triggers of Hot Flashes in Menopause

Menopausal hot flashes (HFs) may potentially elevate inflammatory biomarkers (IB). Neutrophil-to-Lymphocyte Ratio (NLR) and Lymphocyte-to-Monocyte Ratio (LMR) are gaining attention as accessible and cost-effective measures of IB. This study explores the association between these biomarkers and HFs in menopause. This cross-sectional study included healthy menopausal women aged ۴۰-۶۰ in groups without HFs (n꞊۴۰) and with HFs (n꞊۱۲۰) using consecutive sampling. The women experiencing HFs recorded HFs number on a card over two weeks. We reckoned the HFs severity using the modified Kupperman index. We measured the Complete Blood Count and computed NLR and LMR. We conducted multiple and ordinal logistic regression analyses. The median of NLR and LMR had no significant difference between the two groups. There were significant discrepancies in NLR among HFs severity-based groups, contrary to LMR. NLR had an elevating impact on HFs severity as determined by ordinal logistic regression (Odds Ratio꞊۲.۱۸۰, ۹۵% CI: ۱.۲۷۰-۳.۷۴۴). Our research indicated that cumulative changes in NLR may be connected to the HFs severity. Concerning the possible association between HFs and endothelial dysfunction, adjusting NLR in perimenopause seems to control HFs and their probable consequences. It is reasonable to conduct longitudinal studies to clarify the causal relationship between inflammation and HFs.

کلیدواژه ها:

Hot Flashes” ، “Lymphocytes” ، “Menopause” ، “Monocytes” ، “Neutrophils”