Natural Killer Cells and Endometriosis: A Complex Relationship with Therapeutic Implications

Objective: Endometriosis is a benign disease, that includes a condition in which uterine endometrial cells grow in areas other than the uterus and cause periodic bleeding in these areas. Various hypotheses have been proposed regarding the causes of these conditions, but until now researchers have not reached a definitive hypothesis. The important point is the involvement of different immune cells in the processes related to these conditions, like natural killer (NK) cells. These cells, with their high inherent capabilities, can accurately diagnose endometriosis sites and have a very high impact on the treatment of these conditions. Therefore, the therapeutic combination of NK cells with endometriosis is a new approach in gynecology.Results: In this article, collect the latest data regarding the relationship between endometriosis pathology and its treatment with NK cells. Also, the factors involved and susceptible in this relationship were studied to obtain the best approach in this regard.Conclusion: NK cells are one of the most important cells involved in the pathogenesis of endometriosis. Considering the key role of these cells and related factors, it is possible to design a new approach in this regard and provide better treatment of endometriosis.

کلیدواژه ها:

Endometriosis ، Killer Cells ، Natural ، Interleukins ، Combined Modality Therapy.