The Potential Therapeutic Effects of Quercetin in Type ۱ Diabetes: Targeting Essential Genes and Pathways

Type ۱ diabetes (T۱DM) is characterized by severe insulin deficiency caused by chronic andprogressive destruction of pancreatic β cells by the immune system. Quercetin (۳,۳,۴,۵,۷-pentahydroxyflavone) is a dietary flavonoid and bioactive compound that is abundantly found in variousfruits and vegetables. Quercetin has significant blood sugar-lowering effects, stabilization of long-terminsulin secretion, and islet regeneration. In the pancreas, it is not dangerous. The purpose of this studywas to use integrated bioinformatics analysis to clarify key candidate genes and pathways in T۱DM.Inthis study, the Query and Limma package from GSE۱۵۶۹۰۸ of the Gene Expression Omnibus (GEO)were used to analyze differentially expressed genes (DEGs). A protein-protein interaction (PPI)network, gene ontology (GO), and REACTOME pathway enrichment analyses were constructed andanalyzed. Drug metabolism, arachidonic acid metabolism, the HIF-۱ signaling pathway, and the cGMPPKGsignaling pathway are the main metabolic pathways in which DEGs are enriched, according to theresults of the GO and REACTOME enrichment analyses. Finally, we examined the genes related to type۱ diabetes that are targeted by quercetin XDH, PDE۵A, PLG, TOP۲A, INSR, GLO۱, MPO, ALOX۱۲,and we concluded that quercetin may improve type ۱ diabetes by targeting these genes.

کلیدواژه ها:

Bioinformatics ، Type ۱ diabetes ، Quercetin ، Differentially expressed genes ، Enrichment analysis