pH-Sensitive biosystem based on laponite RD/chitosan/polyvinyl alcoholhydrogels for controlled delivery of curcumin to breast cancer cells

In this study, a pH-responsive hydrogels based on laponite rapid dispersion (Lap®)/chitosan (CS)/polyvinyl alcohol(PVA) designed and was used for controlled delivery of the anticancer drug curcumin (CUR). First, it wasaccomplished by dissolving CUR in Lap® dispersion under the influence of the pH of the environment. Then, inthe presence of Lap®CUR cross-linking was incorporated between CS and PVA polymers. The in vitro drug releaseprofiles confirmed a pH-responsive controlled release of CUR in acidic pH for all hydrogels. Meanwhile, in vitrohemolysis, antioxidant and antibacterial tests revealed that the prepared hydrogels have good blood compatibility,excellent antioxidant properties, and antibacterial activity. Based on the obtained results, the designed hydrogelscould be potentially applied as pH-controlled drug delivery systems for cancer therapy.

کلیدواژه ها:

Chitosan ، Laponite RD ، pH-Responsive ، Hydrogels ، Curcumin