Investigation of sustained release of Centella Asiatica extract from Fe-MOFreinforced gelatin-based hydrogels

The goal of this study is to investigate the sustained release of Centella Asiatica (CA) extract from the gelatin-basedhydrogels reinforced with MIL-۵۳(Fe) (Fe-MOF) for the potential use as wound dressing. To achieve antibacterialactivity, the prepared polymer nanocomposite wound dressing hydrogel was loaded by CA extract. FESEM imagesrepresented a lot of interconnected pores within the network of the nanocomposite hydrogels leading to a higherwater absorption capacity and drug encapsulation. The relase results showed that the prepared hydrogels showsustained release behavior. The antibacterial activity of prepared nanocomposite hydrogels was investigated by discdiffusion method revealing the significant inhibition zone growth for gram-positive and gram-negative bacteria.Cytotoxicity results showed that the prepared hydrogels are biocompatible. So, the prepared hydrogel are goodcandidate for potential wound dressing applications.

کلیدواژه ها:

Polymer nanocomposite ، Sustained release ، Antibacterial ، Centella Asiatica ، Wound dressing