Using Coaxial Electrospray to Produce Polysorbat ۸۰ coated nanoparticlesfor Use in Magnetic Resonance Imaging

Magnetic Resonance Imaging (MRI) is one of the widely used methods in the diagnosis of diseases.A group of commercial contrast agents used in MRI have the weakness of low percentage ofmagnetite per unit of particle volume and in some cases they do not create enough image contrast. Inthis research, magnetite and oleic acid capped magnetite nanoparticles were synthesised and coverdby polysorbat ۸۰ using co-axial electrospraying method. According to the results of the in-vitro MRItests, increasing the molar concentration of iron causes a further decrease in T۲* relaxation times andsignal intensity in MRI images. Also, the results showed that the hydrophilic polysorbate ۸۰ coatingcan increase the relaxivity and image contrast compared to the Feridex commercial sample.

کلیدواژه ها:

MRI ، Polysorbat ۸۰ ، Magnetite ، Coaxial Electrospray ، Contrast Agent