Improving the performance of contrast agents used in MRI by usingpolymer particles loaded with superparamagnetic nanoparticles

MRI is one of the widely used methods in the diagnosis of diseases. A group of commercial drugsused in MRI have the weakness of low percentage of magnetite per unit of particle volume and insome cases they do not create enough image contrast. In this research, magnetite nanoparticles coatedwith oleic acid were made and loaded in PLGA particles using electrospraying method.According to the results of the MRI test, increasing the molar concentration of iron causes a furtherdecrease in T۲* relaxation times and signal intensity in MRI images. In addition, in the case that themolar concentration of iron in sets of microparticles is equal, the lateral comfort increases with theincrease of magnetite density in the loaded microparticle.

کلیدواژه ها:

MRI ، PLGA ، oleic acid ، Magnetite ، Electrospray