Investigation of clinical and paraclinical consequences of tramadol poisoning and related factors

Tramadol, is frequently misused and leading to an increase in cases of overdose and poisoning worldwide. This study aimed to investigate the clinical and paraclinical consequences of tramadol poisoning and related factors. This was a retrospective study performed on patients with acute tramadol poisoning who were referred to the Amir Al-Momenin Hospital Emergency Department, Zabol, during ۲۰۱۹-۲۰۲۰. Patients’ socio-demographic information and clinical and paraclinical manifestations were collected in a predesigned checklist. Overall, ۷۱ subjects were included in this study. The mean dose of tramadol was ۶۴۰.۱۴ ± ۵۲۱ mg. Seizures occurred in ۱۷ subjects that were not dose-dependent. In patients who died or were in a coma, pH, bicarbonate (HCO۳ ), and oxygen saturation (O۲ sat) levels decreased, while PCO۲ levels increased significantly (P < ۰.۰۵). The dose of tramadol used in the poisoning of this substance played no role in the course of the disease and the prognosis of patients, but low pH, HCO۳ , O۲ sat, and high CO۲ pressure could be related to the outcome of these patients.