The crosslinked metal-complexed with porous chitosan‑based hydrogels of Cu(II), Zn(II), Hg(II), Ag(I), Al(III) and Fe(III) ions

It has been found that hydrogels that exhibit good mechanical properties and possess antibacterial activity are suitable candidates for many biomedical applications [۱]. With innovative approaches such as the incorporation of metallic ions and nanoparticles, these hydrogels offer a sophisticated platform to address the global challenge of biomedical [۲, ۳].These hydrogels are formed by mixing CS and Micelle with schiff base, creating iminium ion crosslinks with metallic salts without hazardous crosslinkers. FTIR analysis showed metal ions binding to amino and hydroxyl groups on CS, enhancing hydrogelation. SEM revealed that freeze‑dried hydrogels possess a crosslinked, porous structure influenced by various metal ions. The mixture of activated CS-g-Micelle and metallic salt solutions produced the hydrogels within the gelation time reported. A reversed vial test was used to visually identify hydrogel formation. According to report, the gelation time for the Ag+ hydrogel is ۳ h, while the gelation time for Fe۳+ and Zn۲+ is ۴ h, Cu۲+ and Hg۲+ is ۶ h, and Al۳+ is ۲۴ h at the same pH (۷.۴) range. These values suggest that the CS-g- Micelle-Ag+ hydrogel has the fastest gelation time, followed by the Fe۳+ and Zn۲+ hydrogel and then the Cu۲+ and Hg۲+ at last Al۳+ hydrogel. Therefore, this process one of the novels reported procedures for the hydrogelation with porous structures and good elastic nature for wound dressing applications.

کلیدواژه ها:

chitosan ، hydrogel ، metal crosslinking ، porous structure