The Oncogenic Potential of IQ Motif-Containing GTPase-Activating Protein۳ in Human Bladder Cancer: An In-Silico Analysis

Introduction: IQ motif-containing GTPase-activating protein۳ (IQGAP۳) contributes to the progression of bladder urothelial carcinoma (BLCA), but its mechanisms are not systematically specified. Due to the oncogenic potential of IQGAP۳, the current in-silico study intended to elucidate IQGAP۳'s role in BLCA progression. Materials and Methods: Many bioinformatics tools, including UALCAN, Kaplan–Meier plotter, TNMplot, cBioPortal, GeneMania, Enrichr, TIMER۲, muTarget, and UCSC Xena, were applied in the current study. Results: The IQGAP۳ level was more pronouncedly raised in BLCA tissues than in normal bladder tissues, and its increased expression was related to the advanced stage and higher grade. Enhanced IQGAP۳ expression could result from its genetic alteration. Moreover, the mutation in P۵۳ and RB۱ genes was robustly associated with increased IQGAP۳ expression. Besides, IQGAP۳ correlative genes were dominantly involved in the cell cycle. On the other hand, IQGAP۳ upregulation influenced immune checkpoint levels in the tumor microenvironment. Conclusion: The in-silico findings suggested that IQGAP۳ overexpression could be a crucial biomarker in BLCA.

کلیدواژه ها:

Bioinformatics ، Bladder cancer ، IQGAP۳ ، Oncogene