The oral effect of Centella asiati on burn wound healing: a randomized clinical trial

Introduction: Burns and their resulting wounds are a global injury. Finding natural ingredients to speed up wound healing in patients with fewer side effects can be valuable. The aim of this study was to evaluate the oral effect of extract of Centella Asiati on pain and the healing process of burn wounds. Methods: This study is a clinical trial in which ۷۶ patients admitted to the burn ward were included in the study after considering the inclusion criteria and were randomly divided into two groups of intervention (n = ۳۸) and control (n = ۳۸). Patients' wounds were first examined on the seventh and fifteenth days with the Bets-Jensen instrument. The intervention group, in addition to the usual antibiotic treatments, received capsules containing ۲۰۰ mg of Centella Asiati twice daily (۸ am and ۸ pm) and the control group received capsules containing ۲۰۰ mg of starch twice daily. The results were analyzed using descriptive statistics and inferential statistics and SPSS statistical software. Findings: The mean burn pain score after consuming Centella asiatica extract showed a significant improvement in the intervention group compared to the control group (p<۰.۰۰۱). The average wound healing score in the intervention group compared to the control group did not show significant improvement compared to the control group (p<۰.۵۶۱). However, size (p<۰.۵۶۱), undermining (p<۰.۰۲۳), necrotic tissue amount (p<۰.۰۱۵) and tissue granulation (p<۰.۰۰۱) had improved significantly in the intervention group. In addition, the results showed that Peripheral tissue edema (p<۰.۰۰۸) in the control group had a significant decrease compared to the intervention group. Conclusion: According to the results of this study, the oral Centella asiatica extract reduced pain in patients with burn, however, it did not affect wound healing, although it improved a number of wound healing indicators. Similar studies on larger sample using other wound measurement tools are recommended.

کلیدواژه ها:

Burn ، Wound healing ، Centella Asiati