The role of serum uric acid in predicting left ventricular function and outcomes in patients with STEMI following PCI

Objectives: Percutaneous coronary intervention (PCI) is the preferred treatment for ST-elevation myocardial infarction (STEMI); however, reduced left ventricular ejection fraction (LVEF) remains a critical issue post-PCI. Serum uric acid (SUA) has emerged as a biomarker linked to cardiovascular events and may be associated with LVEF. This study aims to investigate the relationship between SUA levels and LVEF in STEMI patients treated with primary PCI and identify potential biomarkers for predicting patient outcomes. Methods: This prospective study was conducted at Afshar Hospital, Shahid Sadoughi University of Medical Sciences of Yazd, from September ۲۰۱۹ to March ۲۰۲۱. Participants included ۲۵۴ consecutive ST-elevation myocardial infarction (STEMI) patients undergoing primary PCI. Exclusion criteria were contraindications for angiography, history of myocardial infarction, PCI, CABG, NSTEMI, thrombolytic treatment, kidney diseases, gout, or alcoholism. Demographic data, clinical history, SUA levels, and echocardiographic parameters were collected. Statistical analysis was performed using SPSS version ۲۰.۰, with significance at p<۰.۰۵. Results: ۸۱.۴۹% of patients were male, with a mean age of ۵۷.۷±۱۱.۴۷ years. Hypertension was the most prevalent condition (۴۲.۹%). SUA levels did not significantly differ between patients with LVEF below and above ۴۰% (p=۰.۳۹). However, smoking was significantly associated with reduced LVEF (p<۰.۰۰۱). A weak negative correlation between SUA and LVEF was observed in males (p=۰.۰۱۲) but not in females (p=۰.۰۹۷). Overall, a weak negative correlation between SUA and LVEF was statistically significant (p=۰.۰۵). Conclusions: Our findings revealed a weak but statistically significant overall negative correlation between SUA and EF. Further research with larger, more diverse populations is necessary to elucidate the relationship between SUA and cardiac function in STEMI patients.

کلیدواژه ها:

ST-elevation myocardial infarction ، Serum uric acid ، percutaneous coronary intervention