Evaluation of PVA composite nanofibers for drug delivery

In this study, we employed the electrospinning technique to fabricate metformin hydrochloride-loadednanofibers using a PVA polymer materials. To mitigate the rapid dissolution of these nanofibers in a PBS medium,a cross-linking process was utilized. The drug release profile was monitored for a duration of ۴۸ hours using aUV-VIS device. The morphology of the nanofibers was examined using FESEM imaging, while EDX analysis andmapping were conducted to identify and quantify the elemental composition of the sample and its spatialdistribution. Our findings indicate that electrospinning is an economical and effective method for the productionof the desired nanofibers. Successful drug distribution within the fibers was achieved, and the application ofcross-linking effectively reduced the high solubility of the nanofibers in aqueous environments, facilitating asustained and stable drug release over a ۴۸-hour period

کلیدواژه ها:

drug delivery ، drug release ، nanofibers ، electrospinning ، polyvinyl alcohol ، metformin hydrochloride