Synthesis of ethyl ۵-aryl-۱H-tetrazole-۱-carboxylate and ethyl ۵-aryl-۲H-tetrazole-۲-carboxylate through the reaction of tetrazole derivatives with ethyl chloroformate in thepresence of N,N-diisopropylethylamine

Increasing interest in tetrazoles and tetrazole-based materials in the recent century has been followedby enormous research efforts devoted to synthesizing various materials based on these five-memberedheterocyclic compounds, which basically contain four nitrogen atoms. The wide field of tetrazole applications asefficient, air-stable, and inexpensive materials has drawn attention to the methods to synthesize various kindsof tetrazoles and their derivatives. In this project, ۵-phenyl-۱H-tetrazole-۱-carboxylate and ۵-phenyl-۲Htetrazole-۲-carboxylate are synthesized by the reaction of ۵-aryl(aryloxy)tetrazole (or ۵-aryl ۱H-tetrazole) withethyl chloroformate in tetrahydrofuran through N-H bond activation in the presence of DIPEA (N,NDiisopropylethylamine).All the synthesized compounds are characterized by FT-IR, ۱H and ۱۳C NMR.

کلیدواژه ها:

Ethyl ۵-aryl-۱H-tetrazole-۱-carboxylate ، Ethyl ۵-aryl-۲H-tetrazole-۲-carboxylate ، DIPEA ، Ethylchloroformate ، Tetrahydrofuran