Polymeric Prodrugs of Mefenamic Acid Based on Glycidyl Methacrylate: Synthesis,Characterization and In-vitro Evaluation

This work describes the synthesis, characterization and in-vitro evaluation of mefenamic acid polymericprodrugs based on glycidyl methacrylate. Hydrolysis of polymeric prodrugs in different buffer solutions showedthat the release rate of mefenamic acid from polymeric prodrugs strongly depends on the hydrophilicity ofpolymer and pH conditions of hydrolysis medium.

کلیدواژه ها:

Mefenamic acid ، Esterification ، Polymeric prodrugs