Phosphoramidate synthesis via Atherton-Todd reaction in the presence of Dimethylsulfoxide as a mild oxidant

A simple and efficient protocol has been developed for the synthesis of phosphoramidate viaAtherton-Todd reaction in the presence of dimethyl sulfoxide (DMSO) and sodium iodide. This protocol ismetal free, easy to conduct and can be scaled-up. Various phosphoramidates are readily obtained in moderateto excellent yields

کلیدواژه ها:

Dimethyl sulfoxide (DMSO) ، Phosphoramidate ، Atherton-Todd reaction