Designing new candidates of CBP/EP۳۰۰ bromodomain inhibitors for prostate cancertreatment through docking and quantitative structure-activity relationship methods

In this study, quantitative structure_activity relationship (QSAR) for ۱-(۱H-indol-۱-yl)ethanonederivatives as potent and selective CBP/EP۳۰۰ bromodomain inhibitors in treatment of prostate cancer wasperformed based on molecularly docked structures. Finally, using the best QSAR model obtained by GSA-ANNmethod, new candidates of this class were introduced as compounds that can be further evaluated in cancertreatment.

کلیدواژه ها:

Docking study ، QSAR study ، prostate cancer ، gravitational search algorithm ، drug design