Amphiphilic polyurethane nanomicelles responsive to enzyme in drug delivery system

Amphiphilic multiblock polyurethane based on polyethylene glycol and polycaprolactonebiocompatible and biodegradable was synthesized and characterized. The enzyme sensitivity was studied by UVVisand DLS. The loaded DOX drug was released at a fast rate in the presence of lipase enzyme. Cytotoxicity(MTT) and staining of cell nuclei (DAPI) proved that PU micelles were non-toxic, while DOX-loaded micellesshowed cytotoxicity to cancer cells, which indicated the potential application of this PU in drug delivery system

کلیدواژه ها:

Amphiphilic polyurethane ، Micelles ، drug delivery ، Enzyme-responsivenes