Gastroretentive Drug Delivery System: Exploring a Novel Hydrogel loaded withMetronidazole.

This study presents a metronidazole-loaded hydrogel for gastroretentive drug delivery. UtilizingDMAEMA as the monomer and TEGDA/MBA as cross-linkers, the hydrogel exhibited an amorphousmorphology. Investigation of cross-linking agents revealed the superior drug release profile of the hydrogelcontaining ۰.۵% TEGDA, prepared through freeze-drying. This promising hydrogel demonstrates potential forlocalized drug delivery, emphasizing the crucial role of physicochemical properties in governing drug release.

کلیدواژه ها:

Hydrogel ، Gastroretentive drug delivery ، Metronidazole ، Radical polymerization