Core-shell Cu-based metal-organic framework coated with doxorubicin imprintedpolymer: As a PH-responsive anticancer nanocarrier

Recent research has increasingly received more attention to molecularly imprinted polymers (MIPs)and their application in biomedical nanoplatforms. In this study, an innovative doxorubicin (DOX) imprintedpolymer via the precipitation-free radical polymerization strategy was developed as a shell on the Cu-basedmetal-organic framework (MOF) as a core for the drug delivery system. The prepared materials werecharacterized by different analyses such as Fourier transform infrared (FT-IR), scanning electron microscopy(SEM), and X-ray diffraction (XRD). The binding kinetics of DOX established specific recognition binding sites inthe core-shell nanoscale molecularly imprinted polymer structure. In vitro drug release behaviors exhibited apH-controlled release in a indicated that a DOX-loaded nanocarrier against cancer cells has notable cytotoxicity.According to the obtained results, the prepared pH-responsive core-shell has the potential to be employed asan anticancer drug delivery platform.

کلیدواژه ها:

nanocarrier ، molecular imprinted polymer ، doxorubicin ، metal-organic frameworks ، drug delivery