Synthesis of Functionalized Quinolines from Aniline, Isocyanides and Acetylenedicarboxylate via Intramolecular C-H Activation Reactions

The one-pot synthesis of a novel class of substituted quinoline derivatives is achieved via the Cucatalyzedintramolecular C-H activation reaction between aniline, isocyanides and acetylene dicarboxylate inMeCN at room temperature. The advantages of this method are available starting materials-catalyst, one-potconditions, no column chromatography and high yield of products.

کلیدواژه ها:

C-H Activation ، Acetylene dicarboxylate ، Quinoline ، Isocyanides ، Aniline