Extraction of the anti-inflammatory drug from biological material: Experimental designand optimization of effective parameters in extraction

The aim of this study is to extract naringin from the grapefruit using water as the solvent during theextraction process. The optimal parameters, including time, pH, and sample-to-solvent ratio, were determinedusing Design-Expert (DOE) software. The temperature was maintained constant at ۵۵ ℃. The concentration ofthe samples was determined through spectrophotometric analysis. The ANOVA model for the water solventshowed a correlation coefficient of ۰.۹۶۴۶ at a %۹۵ confidence level.

کلیدواژه ها:

Extraction ، Naringin ، response surface method ، effective parameters