Synthesis, biological evaluation and molecular docking of new dihydropyridine derivationsas tyrosinase inhibitors
سال انتشار: 1403
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 68
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شناسه ملی سند علمی:
NICEC22_218
تاریخ نمایه سازی: 7 مرداد 1403
چکیده مقاله:
Three fused ۱,۴-dihydropyridine derivatives, (۴a), (۴b), and (۴c), were synthesized as potentialtyrosinase inhibitors. Compound (۴a) and (۴b) demonstrated notable inhibitory activity, with IC۵۰ values of۱۴۷.۹۱ ± ۸.۳۸ μM and ۱۳۸.۰۳ ± ۶.۴۲ μM, respectively. Molecular docking affirmed these findings, enhancinginsights into tyrosinase inhibitor design.
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نویسندگان
Mohammad Azimi
Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
Zahra Najafi
Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
Aida Iraji
Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Asrin Bahmani
Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
Gholamabbas Chehardoli
Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.