Inhibitory effect of cigarette smoke on singlet oxygen

Singlet oxygen is a type of free radical that plays an important role in chemical and biologicalprocesses. Singlet oxygen is the electron-excited type of molecular oxygen that is usually produced usingphotosensitizers and light but it also is generated in the biological systems by chemical process. Singlet oxygenis one of reactive oxygen spices (ROS), which is toxic and dangerous for biological systems. Anthracene as achemical probe that is usually used to trap the singlet oxygen and then detection and quantification of singletoxygen can be measured based on absorbance. This study aims to investigate the synergic or non-synergiceffect of cigarette smoke on the production or scavenging of singlet oxygen. For this purpose, anthracene asindicator of singlet oxygen was used. In this study, oxidation of anthracene declared that rate of singlet oxygenquenching in the presence of mix of hydroalcoholic extract of Crataegus and smoke bubbling, cigarette smokebubbling, and hydroalcoholic extract of Crataegus were decreased ۷۲.۴۳%, ۶۵.۸۲%, and ۶۲.۶۴% respectivelywhich reveals cigarette smoke has an efficient role on singlet oxygen scavenging similar to Crataegus as asource of flavonoid compounds.

کلیدواژه ها:

Singlet Oxygen ، Cigarette smoke ، Oxidative stress ، photosensitizer ، Reactive oxygen species