Hydrogen bonded organic framework for pipette tip micro-solid phase extraction: aneffective approach for determination of meloxicam in Urine and plasma samples

In this work, an in situ synthesis of hydrogen organic frameworks@cotton was reported that wasutilized as a pipette tip micro-solid phase extraction (PTMSPE) for the pretreatment and determination ofmeloxicam in Urine and plasma samples. The synthesized was characterized by various theoretical, spectral, andmicroscopic studies such as Fourier-transform infrared spectroscopy (FT-IR), Nuclear Magnetic Resonance(NMR), X-ray diffraction (XRD) and scanning electron microscopy (SEM). Furthermore, the extraction conditionswere also optimized, and the extraction mechanisms were analyzed. Ultimately PT-SPE with the HOF@cottonsorbent was coupled with UV-Vis spectroscopy to create a sensitive and simple method for the quantitativeanalysis of meloxicam in Urine and plasma samples. The results of this work demonstrate that the proposedstrategy is an effective option for the analysis of meloxicam in biological samples.

کلیدواژه ها:

Hydrogen bonded organic framework ، pipette tip micro-solid phase extraction ، meloxicam