Utility of 6-amino-2-thiouracil as a precursor for the synthesis of pyrido[2,3-d]pyrimidine derivatives

A series of pyrido[2,3-d]pyrimidine derivatives were synthesized via a thermal cyclocondensation reaction of an arylaldehyde, 5-cyanoacetylpyrimidine in DMF at 120 °C without catalyst. This protocol has the advantages of easier workup, lower cost, milder reaction, and good yields.

کلیدواژه ها:

Pyrido[2 ، 3-d]pyrimidine ، Thermal cyclocondensation ، 5-Cyanoacetylpyrimidine