Evaluation of phosphorus metabolic changes in relation toepileptogenic side in Temporal lobe epilepsy patients usingphosphorus magnetic resonance spectroscopy (۳۱P-MRS)

Temporal lobe epilepsy (TLE) is the most common type of focal epilepsy.It isusually treated surgically if necessary.Unfortunately, about ۲۵-۳۰% of the patient populationhas no visible lesions on clinical MRI scan. Without anatomical abnormalities, the success ofsurgical treatment is significantly reduced. However, metabolic abnormalities may determinethe exact location of epileptic tissue in this group. Magnetic Resonance Imaging (MRS) is atechnique that can detect and measure the concentration of important metabolic molecules inthe tissue and show cellular metabolism.method: In this dissertation, ۸ patients with non-lesioned TLE temporal lobe epilepsy werestudied using the ۳۱P-MRS phosphor magnetic resonance spectroscopy technique on a ۳.۰TMRI machine.Results: The results showed that PCr / Pi, PCr / ATP and γ-ATP / Pi metabolites decreasedby ۱۹%, ۷% and ۱۷% in the affected areas, respectively, and Pi metabolites increased by۱۸%, with a significant value of ۰.۰۵ compared to the healthy opposite side.Discussion and conclusion: Metabolic changes in the hippocampus are associated with seizurelateralization. Patients showed changes in the levels of PCr / Pi, PCr / ATP, y-ATP / Pi, andPi metabolites. These results are consistent with previous studies and can also be used todifferentiate the involved side in most patients using these metabolites

کلیدواژه ها:

Epilepsy ، Temporal lobe epilepsy ، ۳۱P-MRS phosphor magnetic resonancespectroscopy ، PCr / ATP ، Pi ،