Exploring aspartic acid D-repeat polymorphism as a potential risk factor for primary hip osteoarthritis in the Iranian population

Background: The ASPN gene encodes a cartilage extracellular protein (Asporin) that is known to be involved in the pathological paths of osteoarthritis (OA). Many research efforts have explored the link between aspartic acid D-repeat polymorphism in the asporin (ASPN) gene and the risk of OA susceptibility, yet the findings are inconsistent. Our study involved a case-control analysis to examine the relationship between D allele polymorphism in asporin and primary hip osteoarthritis (HOA) among the Iranian population.Methods: The asporin D repeat polymorphism was genotyped in primary HOA patients (N=۷۰) and healthy controls (N=۷۰). Each group consisted of ۲۸ women and ۴۲ men. Patients were classified into three subgroups based on the radiographic severity of osteoarthritis. Statistical analysis was performed on gender, severity, and primary HOA position.Odds ratios (ORs) along with ۹۵% confidence intervals (۹۵% CIs) were utilized to assess the association between D-repeats in the ASPN gene and primary hip osteoarthritis.Results: Three common D-repeat variants (D۱۳, D۱۴, and D۱۵) of the ASPN gene were obtained. The most frequent allele in the patient group was observed at D۱۳, while it was D۱۵ among controls. In both cohorts, the least frequent allele was D۱۴. Our findings indicate no statistically significant association between any D-repeats with primary HOA according to the sex of patients or the severity of the disease.Conclusion: Our findings indicate that polymorphisms in the ASPN D-repeat are not linked to a higher risk of primary hip osteoarthritis (HOA) in the Iranian population.  However, future large studies are needed to validate these findings.

کلیدواژه ها:

Asporin gene ، Primary hip osteoarthritis ، Polymorphism ، Iran