Outcome and Prognostic Factors of Low-Grade Astrocytoma: Namazi Hospital, Shiraz, Iran (۲۰۰۶–۲۰۱۳)

Introduction: Primary brain tumors, although not among the most common site of tumors, are considered an important pathology, due to their high mortality rate. Astrocytoma is a glial brain tumor with a high mortality rate. The predictors of the patients’ outcome is thus of great importance. In the present study, we investigated the results of ۷–year follow–up of patients with astrocytoma in order to determine the prognostic factors associated with patients’ survival. Methods: In this cross–sectional study, ۱۱۵ patients suffering from astrocytoma grade II, who referred to radio–oncology department of Nemazee hospital between ۲۰۰۶ and ۲۰۱۳, were included. The patients’ overall survival (OS) and disease–free survival (DFS) were recorded and their difference according to demographic and clinical characteristics of patients, as well as the treatment used, was evaluated using SPSS v.۲۵.Results: Mean age of patients was ۳۵.۳۴±۱۵.۱۷ years; most were younger than ۴۰ years old (۷۱%) and men (۵۹%). Mean OS and DFS were ۷۴.۹۰±۴۳.۰۵ and ۲۶.۶۱±۲۶.۹۷ months, respectively. Patients younger than ۴۰ had a significantly longer mean OS (۸۴.۰۴±۳۷.۹۳ vs. ۵۳.۰۴±۴۷.۴۱ months; P=۰.۰۰۴). Mean DFS was different according to chemotherapy and dose of radiotherapy (P=۰.۰۴۱ and ۰.۰۱, respectively), while OS was not (P>۰.۰۵). Conclusion: Considering the difference in outcome of patients, specifically DFS, according to the performance of chemotherapy and the dose of radiotherapy, it is recommended to pay greater attention to appropriate choice of treatment strategy of patients with astrocytoma. Further randomized controlled studies are required to determine the predictors of patients’ outcome.

کلیدواژه ها:

Brain neoplasms ، astrocytoma ، radiotherapy ، Chemotherapy