Anti-diabetic Effects of Caucasian whortleberry and Ferula Extract on Blood Biochemical Factors, Liver and Kidney Histology in Streptozotocin-induced Diabetic Mice

One of the biggest issues facing modern societies is diabetes, which is becoming more prevalent as a result of changes in daily routines. Numerous studies are currently being conducted to determine the impact of herbal medications on diabetes, given the negative side effects of chemical treatments used to treat the condition. The present study aimed to compare the antidiabetic effects of Caucasian whortleberry (Vaccinium arctostaphylos L.) methanolic extract and Ferula brewed extract (Ferula tea). To this end, ۴۰ mice were given ۲۰۰ mg/kg of streptozotocin intraperitoneally to induce diabetes in them. The mice were then divided into six groups, each consisting of ten mice: Group ۱ included healthy mice that did not receive any treatment and was mentioned as the control; Group ۲ was considered the diabetic control group and received a daily treatment of water; Group ۳ and ۴ received a daily treatment of the chemical drugs Acarbose or Metformin, which are regularly and separately used at a dose of ۱۰۰ mg/kg of each drug. Group ۵ received a daily treatment of ۲۵۰ mg/kg of Caucasian whortleberry methanolic extract, and group ۶ received a daily treatment of ۳۰۰ mg/kg of Ferula tea. After the ۴۰-day trial, the results showed that Caucasian whortleberry methanolic extract, Ferula tea, and Acarbose significantly reduced serum glucose levels compared to the control. In addition, Caucasian whortleberry methanolic extract caused a significant reduction in triglycerides and alkaline phosphatase.Abbreviations: STZ: Streptozotocin, HDL: High-Density Lipoproteins, LDL: Low-Density Lipoproteins, SGOT: Serum Glutamic Oxaloacetic Transaminase, ALP: Alkaline Phosphatase, HbA۱c: Hemoglobin A۱c, SGPT: Serum Glutamic Pyruvic Transaminase, CGA: Chlorogenic Acid. FBS: Fast Blood Sugar.

کلیدواژه ها:

Caucasian whortleberry Methanolic Extract ، Anti-diabetic Effects ، Streptozotocin-induced Diabetic Mice ، Ferula Tea ، Medical plants