Impact of high-intensity interval training on Mir-۲۱ and Mir-۱۲۲ expression and metabolic parameters in middle-aged men with metabolic syndrome
محل انتشار: فصلنامه زیست پزشکی جرجانی، دوره: 11، شماره: 3
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 84
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شناسه ملی سند علمی:
JR_JOBJ-11-3_006
تاریخ نمایه سازی: 18 اردیبهشت 1403
چکیده مقاله:
Background: Metabolic syndrome, a problem of the present age, is a combination of several medical issues, and miRNAs play important regulatory roles in metabolic syndrome. Many studies indicate that high-intensity interval training (HITT) may improve risk factors for metabolic syndrome.
This study aimed to investigate the effect of ۸ weeks of HIIT training on the changes in miR-۲۱, miR-۱۲۲, alanine aminotransferase (ALT), aspartate aminotransferase (AST), low-density lipoprotein (LDL), lipid profile, and glucose.
Methods: In this quasi-experimental study, middle-aged male (n=۱۹) volunteers with metabolic syndrome (body mass index (BMI)>۳۰) were randomly assigned to the control (n=۹) and training (n=۱۰) groups. The training program consisted of ۸ weeks of HIIT training with ۴ sets of workouts with an intensity of ۸۰-۹۰% heart rate for the training group (۳ sessions per week during the first ۴ weeks and ۴ sessions per week during the second ۴ weeks). Blood samples were collected from the subjects ۴۸ hours before and after the last training session to analyze miR-۲۱, miR-۱۲۲, ALT, AST, HDL, LDL, triglyceride, cholesterol, and glucose. The within-group and between-group differences of data were analyzed using the paired t-tests and analysis of covariance at a significance level of P˂۰.۰۵ in SPSS software.
Results: This study indicated that HIIT caused a significant decrease in miR-۱۲۲, ALT, AST, triglyceride, cholesterol, glucose, body weight indicators, fat percentage, and BMI (P˂۰.۰۵). Also, a significant increase in miR-۲۱ and HDL levels was observed following HIIT training (P˂۰.۰۵).
Conclusion: HIIT training seems essential in metabolic changes, such as reducing the lipid profile, decreasing glucose, and improving liver damage by affecting miR-۲۱ and miR-۱۲۲ indicators as small regulatory transcripts. However, more extensive studies are needed in this field.
کلیدواژه ها:
نویسندگان
Hamid Reza Zolfi
Department of Physical Education and Sport Science, Technical and Vocational University (TVU), Tabriz, Iran
Amir Shakib
Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran
Zahra Niknam
Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran
zhaleh pashaei
Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran
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