The Effect of Sumac Powder (Rhus Coriaria L) on Homocysteine and High-Sensitivity C-Reactive Protein in Patients with Type ۲ Diabetes Mellitus

Background: High-sensitivity C-reactive protein (hs-CRP), and homocysteine increase along with inflammation in type ۲ diabetes mellitus (T۲DM). The antioxidant properties of sumac might affect homocysteine and hs-CRP levels. We aimed to examine the effects of sumac powder (Rhus Coriaria L) on homocysteine and hs-CRP in patients with T۲DM.Methods: In a single-blinded, randomized controlled clinical trial, conducted in Ardekan city, Yazd, Iran; ۶۰ patients with T۲DM were randomly divided into ۲ groups to consume either low fat yogurt alone in the control group or along with ۶ (۲×۳ grams) grams of sumac powder daily in the intervention group, for ۳ months. Fasting blood samples were used to analyze the fasting blood sugar (FBS), serum homocysteine, and hs-CRP at the baseline and after ۹۰ days. P values <۰.۰۵ were considered statistically significant.Results: Fifty-eight individuals (intervention n=۳۰, control n=۲۸) with a mean age of ۵۲.۳۰±۷.۰۵ years in the intervention, and ۵۱.۶۱±۷.۰۷ years in the control group, finished the study. No significant differences were seen for FBS (p=۰.۹۴) and homocysteine (p=۰.۶۹) changes between the groups; but hs-CRP changes were significantly different between the groups (p=۰.۰۳).Conclusion: Daily consumption of sumac powder for ۳ months may not have a reducing effect on FBS and serum homocysteine. This is while sumac may prevent increment of hs-CRP in patients with T۲DM.

کلیدواژه ها:

Sumac ، Rhus Coriaria ، Homocysteine ، C-reactive protein ، diabetes mellitus