A comparative, simultaneous, and systematic investigation of the number of biomarkersrelated to EMT. A Review

Introduction: Epithelial mesenchymal transition (EMT), which is an important physiological phenomenon inembryonic development and wound healing, is considered a serious challenge for cancer diagnosis andtreatment. The role of EMT in resistance to treatments, escape of cancer cells from the immune system, andsuppression of immune response, invasion, and metastasis have been widely studied and proven, but its specificmarkers still have their real place in cancer control and treatment. They have not found a clinic. And treatmentsare still started and followed regardless. This study, the aim of this study is a comparative, simultaneous, andsystematic investigation of the number of biomarkers related to EMT.Methods: PubMed, Science Direct, Web of Science, and Google Scholar databases were explored up to May۲۰۲۳, using different combinations of the keywords: "Epithelial mesenchymal transition", "biomarker","radiotherapy ", "chemotherapy ", "cancer", and "metastasis".Results: Contrary to expectations, the investigation and prediction of EMT as a very important prognostic factorhave not yet found its room in the clinic, and despite all the efforts made and all the introduced biomarkers,many treatments are still blindly started and continue without considering this important phenotype change atthe beginning and during the treatment. The phenomenon Such as EMT or radiation resistance is multifactorialand cannot be judged by just one marker. Different biomarkers and factors are different from each other in thedegree of influence and power of reflection of the happening events. Therefore, separate studies of differentfactors in separate conditions cannot be the basis of a definite clinical decision for intervention, and it is preciselyfor this reason that most markers end up being introduced and validated at the cellular and preclinical levels. Itwas given that the role of metals, lipids, hormones, vitamins, and various proteins and the effect of each hasbeen investigated in detail, that sometimes these roles are contradictory or complementary to each other, andthis clinical decision to choose a marker and several markers that are separately examined and introduced Itconfronts them with difficulty and confusion.Conclusion: The problem of lack of recognition and introduction of biomarkers, especially biomarkers relatedto EMT, is not the lack of new and efficient markers to enter the clinic, but the lack of comprehensiveness ofstudies, especially comparative studies.

کلیدواژه ها:

Epithelial mesenchymal transition" ، "biomarker" ، " radiotherapy " ، " chemotherapy " ، "cancer