CRISPR-Cas: the effective immune systems in the prokaryotes
سال انتشار: 1393
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 105
فایل این مقاله در 11 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_IJMCM-4-1_001
تاریخ نمایه سازی: 16 اسفند 1402
چکیده مقاله:
Approximately all sequenced archaeal and half of eubacterial genomes have some sort of adaptive immune system, which enables them to target and cleave invading foreign genetic elements by an RNAi-like pathway. CRISPR–Cas (clustered regularly interspaced short palindromic repeats–CRISPR-associated proteins) systems consist of the CRISPR loci with multiple copies of a short repeat sequence separated by variable sequences with similar size that are derived from invaders and cas genes encode proteins involved in RNA binding, endo- and exo-nucleases, helicases, and polymerases activities. There are three main types (I, II and III) of CRISPR/Cas systems. All systems function in three distinct stages: (۱) adaptation, (۲) crRNA biogenesis, and (۳) interference. This review focuses on the features and mechanisms of the CRISPR-Cas systems and current finding about them.
کلیدواژه ها:
نویسندگان
Yalda Vasebi
Department of Plant Protection, Faculty of Agriculture, University of Tabriz.
Reza Khakvar
Department of Plant Protection, Faculty of Agriculture, University of Tabriz.