Comparison of the Expression Level of P۵۳ and Proliferating Cell Nuclear Antigen (PCNA) Genes in the Inflamed and Non-Inflamed Dentigerous Cysts
سال انتشار: 1391
نوع سند: مقاله ژورنالی
زبان: فارسی
مشاهده: 145
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شناسه ملی سند علمی:
JR_JKMU-19-3_001
تاریخ نمایه سازی: 14 اسفند 1402
چکیده مقاله:
Background & Aims: The role of P۵۳ and proliferating cell nuclear antigen (PCNA) genes in inflamed and non-inflamed odontogenic cysts is related to cell proliferation but it is unclear. The aim of this study was immunohistochemical evaluation of P۵۳ and PCNA expression in inflamed and non-inflamed dentigerous cysts Methods: In the present study, ۲۳ dentigerous cysts (۱۲ inflamed and ۱۱ non-inflamed) were surveyed. Three microns slices were got from paraffined blocks and stained with P۵۳ and PCNA antibodies by immunohistochemistry. Slides were seen by oral pathologist with optical microscope (Olympus BX۴۱) in ×۴۰۰ magnification and scored by Allred scoring. Data were analyzed by Mann-Whitney test via SPSS software. Results: Percent of stained cells in inflamed compared non-inflamed dentigerous cyst did not show any significant difference for expression level of P۵۳ and PCNA in basal and suprabasal layers (P> ۰.۰۵). Conclusion: It seems that inflammation does not affect on expression level of P۵۳ and PCNA in dentigerous cyst.
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نویسندگان
M Seyed majidi
Assistant Professor, Department of Oral and Maxillofacial Pathology, School of Dentistry, Babol University of Medical Sciences, Babol, Iran . Dental Materials Research Center, Babol University of Medical Sciences, Babol, Iran
N Keshmii
Students&#۰۳۹; Research Committee, Babol University of Medical Sciences, Babol, Iran
SH Nafarzadeh
Assistant Professor, Department of Oral and Maxillofacial Pathology, School of Dentistry, Babol University of Medical Sciences, Babol, Iran
A Bijhani
Non-communicable Pediatrics Diseases Research Center, Babol University of Medical Sciences, Babol, Iran