Deciphering the Impact of the L۸۵۸R Mutation in EGFR: Computational Insights and Therapeutic Implications in Non-Small-Cell Lung Cancer
محل انتشار: اولین کنفرانس ملی بیوانفورماتیک در مطالعات سرطان
سال انتشار: 1402
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 237
فایل این مقاله در 8 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
MINEPLUS01_003
تاریخ نمایه سازی: 13 اسفند 1402
چکیده مقاله:
This study delves into the L۸۵۸R mutation in the Epidermal Growth Factor Receptor (EGFR) and its impact on lung cancer, specifically non-small-cell lung cancer (NSCLC). Employing computational tools like the DynaMut web server and PSIPRED, we assessed evolutionary conservation, protein stability, flexibility, secondary structure, and interatomic interactions of the EGFR protein. Our findings suggest that the L۸۵۸R mutation, while highly conserved, induces significant changes in the protein's stability, flexibility, and secondary structure, potentially influencing its function. These alterations offer insights into the development of targeted therapies for NSCLC, underscoring the mutation's impact on protein behavior and therapeutic implications. The study highlights the importance of computational predictions in understanding the molecular basis of cancer and suggests the need for experimental validation in future research.
کلیدواژه ها:
Non-Small-Cell Lung Cancer (NSCLC) ، EGFR ، L۸۵۸R mutation ، protein stability ، protein flexibility ، secondary structure ، interatomic interactions
نویسندگان
Seyedeh Yasaman Mousavi
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
Mousavi Jafari
Department of Medical microbiology and virology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran