Evaluation of Antibiotic Susceptibility Pattern of uropathogenic Escherichia coli among Kidney Transplant Recipients in North of Iran

BACKGROUND AND OBJECTIVESUrinary tract infection (UTI) is the most frequent infection complication after kidney transplantation. Morbidity and mortality in kidney transplant recipients (KTRs) that are caused by UTI represents a substantial burden on health care resources. We aimed to investigate antibiotic susceptibility pattern of uropathogenic Escherichia coli (UPEC) in KTRs in North of Iran.MATERIALS AND METHODSA total of ۱۳ E. coli strains isolates were collected from urine among KTRs who were admitted to Razi hospital, Rasht, Iran, in ۲۰۲۱. The isolates were confirmed through phenotypic and genotypic methods. The disk diffusion method was performed for the antibiotic susceptibility pattern of isolates.RESULTS AND DISCUSSIONThe results revealed that the rate of ESBL-producing and multidrug resistant (MDR) isolates was ۷۶.۹ % and ۱۰۰%, respectively. Further analysis of antibiotic susceptibility among strains showed that the highest resistance rates were to ampicillin (۹۲.۳%), ciprofloxacin, cefuroxime and Levofloxacin (۸۴.۵%) and ceftriaxone (۷۶.۹%). On the other hand, the highest susceptibility in addition to carbapenems was toward fosfomycin and nitrofurantoin (۹۲.۳%), amikacin and Gentamicin (۸۴.۵%), cefoxitin and Piperacillin- tazobactam (۷۶.۹%). The ESBLs-producing strains shown significantly resistance to Cefuroxime, Cefepime, Ceftriaxone and ampicillin and susceptibility to nitrofurantoin (P<۰.۰۵).CONCLUSIONOur results showed a remarkable rate of drug resistance among UPEC strains isolated from KTRs in our studied region. Our study suggests the necessity of monitoring an empirical use of antibiotics at a geographical area in order to select an appropriate empirical treatment

کلیدواژه ها:

Escherichia coli ، Kidney transplant ، Antibiotic resistance ، Urinary Tract Infection