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Survey the Prevalence and Antibiotic Susceptibility Pattern of Uropathogens Isolates from Outpatients in North of Iran

سال انتشار: 1402
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 84
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شناسه ملی سند علمی:

MEDISM24_588

تاریخ نمایه سازی: 6 اسفند 1402

چکیده مقاله Survey the Prevalence and Antibiotic Susceptibility Pattern of Uropathogens Isolates from Outpatients in North of Iran

BACKGROUND AND OBJECTIVESUrinary tract infections are one of the most common bacterial infections and are a health problem worldwide. Bacterial agents that cause urinary tract infections include a wide range of gram- negative and gram-positive bacteria. Current treatments for urinary tract infections are less than desirable, and the prevalence of multidrug- resistant uropathogens is increasing.The aim of this study was to evaluate the frequency of uropathogenic strains isolated from outpatients with urinary tract infections and also to evaluate the patterns of antibiotic resistance among them.MATERIALS AND METHODSUropathogenic isolates were collected from urine among outpatients who were admitted to Razi hospital, Rasht, Iran, between 2020 until 2021. Identification of uropathogenic strains was performed according to bacteriological and PCR criteria. The pattern of antibiotic resistance of each of the isolated uropathogenic isolates was evaluated using Kirby-Bauer method.RESULTS AND DISCUSSIONOut of 164 outpatients with urinary tract infections, the prevalence of infection among women was 76.2% and the majority of patients (54.3%) were in the age group of 60 to 80 years and most patients had a history of recurrence of infection (75%). Escherichia coli 136 (82.9%) followed by Klebsiella pneumoniae 16 (9.8%) Staphylococcus aureous 6 (3.7%), Enterococcus species 4 (2.4%) and Enterobacter species 2 (1.2%) were identified as the most uropathogenic isolates. The results revealed that the rate of ESBL-producing isolates was 58.4 %. Among gram-negative uropathogenic strains and producing ESBLs strains, the highest resistance was to ampicillin with 88.5%, ciprofloxacin with 66.3% and Trimethoprim-sulfamethoxazole with 63.8% and the highest susceptibility to fosfomycin with 82.8%, meropenem with 83.1% and imipenem with 79.9%. Gram-positive cocci isolated from urinary tract infections were resistant to penicillin and sensitive to vancomycin.CONCLUSIONOur results showed a remarkable rate of drug resistance among uropathogenic isolates from outpatients with UTIs in our studied region. Our study suggests the necessity of monitoring an empirical use of antibiotics at a geographical area in order to select an appropriate empirical treatment.

کلیدواژه های Survey the Prevalence and Antibiotic Susceptibility Pattern of Uropathogens Isolates from Outpatients in North of Iran:

نویسندگان مقاله Survey the Prevalence and Antibiotic Susceptibility Pattern of Uropathogens Isolates from Outpatients in North of Iran

Sara Darvishvand

Department of Microbiology, Virology and Microbial Toxins, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Raheleh Sheikhi

Department of Microbiology, Virology and Microbial Toxins, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran