Combining antibacterial antibiotics with artemisinin for controlling resistant pathogens

BACKGROUND AND OBJECTIVESNearly ۸۰ years of antibiotic use shows that resistant pathogens emerge a few years after the introduction of an antibiotic. Our study focuses on innovative therapeutic strategies that are currently important against multi-drug-resistant microorganisms, such as plant-derived products.MATERIALS AND METHODSThis research is a review study that examines reputable English-language articles and electronic databases and libraries such as Web of Science, ProQuest, PubMed, Scopus, and the Google Scholar search engine using keywords like antibiotic, antimicrobial resistance, and artemisinin.RESULTS AND DISCUSSIONAntimicrobial resistance is the ability of a microorganism to resist various antimicrobial actions. In this type of resistance, microbes can resist drugs that were once successful against them. The current research needs to look for biomolecules that are themselves antimicrobial and enhance the power of antimicrobials. The phytochemicals of medicinal plants have great potential for development as biological enhancers of antibiotics. Among plants, the Asteraceae family includes a large number of genera, with Artemisia being one of the largest genera worldwide.Artemisia annua L., one of the most recognized species of this genus, contains the compound artemisinin present in glandular trichomes on the surface of leaves and flowers, which has many anti-protozoal activities.CONCLUSIONBased on its antimicrobial potential, A. annua can be used to create a stronger antibiotic formulation for treating drug-resistant bacterial and fungal pathogens

کلیدواژه ها:

Antibiotic ، Antimicrobial resistance ، Artemisia annua ، Artemisinin.