Integrating ۳D graphene with CuO nanoparticles and investigation of its Gram-Positive and Gram-Negative antibacterial properties

سال انتشار: 1402
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 120

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شناسه ملی سند علمی:

MEDISM24_316

تاریخ نمایه سازی: 6 اسفند 1402

چکیده مقاله:

BACKGROUND AND OBJECTIVESRecently, graphene-based nanocomposites have raised significant interest in many different areas, one of which being antibacterial agents where CuO nanoparticle-anchored graphene has shown promising potential. Graphene is considered the most interesting material due to its unique properties, including strong mechanical strength, large surface area, and high resistance to degradation. In this study, a ۳D grapheme/CuO nanocomposite was synthesized, and its antibacterial effects on both Gram-positive and Gram-negative bacteria were examined.MATERIALS AND METHODSThe anti-bacterial and physicochemical properties of ۳D grapheme/CuO nanocomposite were investigated. Furthermore, CuO, ۳DG, and ۳DG /CuO nanocomposite were treated to Acinetobacter baumannii ATCC۱۹۶۰۶ and Staphylococcus aureus ATCC۲۵۹۲۳.RESULTS AND DISCUSSIONThe proposed structure for graphene-based nanocomposites was confirmed by physicochemical investigations. The anti-bacterial property of ۳D grapheme/CuO was demonstrated using the MIC and Time killing assays. Moreover, ۳D grapheme/CuO inhibited A. baumannii ATCC ۱۹۶۰۶ and S. aureus ATCC۲۵۹۲۳ in a dosage and time-dependent manner.CONCLUSIONOur findings suggested that ۳D graphene/CuO nanocomposite could be employed as an anti-bacterial agent.

نویسندگان

Amin Mohsenzadeh

Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Ramin Nasiri

Research Laboratory of Polymer, Department of Organic and Biochemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran

Sahar Pourasgar

Department of Biology, Faculty of Science, Rasht Branch, Islamic Azad University, Rasht, Iran

Sanaz Borji

Department of Biology, Faculty of Science, Rasht Branch, Islamic Azad University, Rasht, Iran

Yasaman Panahian

Research Laboratory of Polymer, Department of Organic and Biochemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran