First assessment of SEN virus in hemophilia patients: A high prevalence in comparison to healthy population

BACKGROUND AND OBJECTIVESHemophilia and transfusion dependent patients are at high risk of blood born viruses including viral hepatitis and non-A non-B agents. SEN virus (SEN-V) is a newly identified blood born virus that is associated with transfusion-induced non-A to E hepatitis. Therefore, this study aimed to investigate the prevalence of SEN-V in hemophilia patients in association to complications and risk factorsMATERIALS AND METHODSThis was a cross sectional case-control study conducted in Hemophilia Center in east of Iran, South Khorasan Province. Blood samples were taken from patients and healthy control population; next demographic and clinical information were taken. The sera samples were subjected for DNA extraction, then SEN-V and its genotype were detected by PCR-based methods and phylogenetic analysis was performed. The collected data were analyzed and interpreted by SPSS۲۲ software.RESULTS AND DISCUSSIONThe mean age of patients was ۲۶.۱۸ ±۱۴.۹۷ and the healthy age was ۴۱.۶۹± ۱۴.۰۵. Among the patients and healthy group, ۹۴.۵% and ۳۶.۴% were male, respectively; the rest were female. Most cases in the patient group had hemophilia type A (۸۵.۵%), then type B (۷.۳%) and. VWD type (۳.۶%) and F and plt type (۱.۸%) were in the next categories. SEN-DNA was detected in ۵۸.۲% of patients and ۲۰% of healthy groups (P-value: ۰.۰۰). Among these, H and D genotypes were found in ۵۹.۴% and ۴۰.۶% of patients and ۶۳.۶% and ۳۶.۴% of healthy groups, respectively. The prevalence of the virus was higher in hemophilia A (۶۳.۸%) and its severe type was much higher (۶۳.۲%).CONCLUSIONThe results of this study showed a very high prevalence of SEN virus in hemophilia patients compared to healthy individuals. These results indicate the need for monitoring and follow-up of this high-risk group in terms of blood-borne pathogens.

کلیدواژه ها:

Hemophilia ، SEN Virus ، Prevalence ، Blood Born Pathogens ، Hepatitis