Investigating design of recombinant vaccine with fusion protein FimH,MrpH,FilC against urinary tract infections by proteus mirabilis: A review

BACKGROUND AND OBJECTIVESUrinary tract infection (UTI) is one of the most common infections in human societies and hospitals. Proteus mirabilis is known as one of the pathogens of urinary tract infection. The most common antigens of Proteus mirabilis are MrpH, FimH, and FliC. This study investigated the immunogenetics of fusion proteins MrpH, FimH , and FliC against urinary infections by Proteus mirabilis.MATERIALS AND METHODSThis study was a descriptive-analytical review that was using the search method and compilation of the original author's online articles in English published in PubMed, Science Direct, and Google Scholar databases. We have used keywords such as Proteus mirabilis, urinary tract infections, FimH, MrpH, and FliC.RESULTS AND DISCUSSIONUrinary tract infection is one of the most common causes of the pathogen Proteus mirabilis in different societies. Protein fusions as adjuvants and epitopes in vaccination were explored to prevent this infection caused by P.mirabilis. FimH, MrpH, and FliC proteins have been characterized by N-terminal domains. Activation of innate and adaptive immunity against UTI by the mentioned bacteria is possible through protein fusion through macrophage-lymphocyte interactions leading to the production of chemokines and cytokines. the design of a monovalent vaccine against It Positive influence in preventing related pathogens has been studied, but more research is needed.CONCLUSIONIn this study, with the help of a wide range of different strategic solutions for the fusion of tMrpH.FliC proteins to design a vaccine against urinary infections (UTIs) by P. mirabilis.

کلیدواژه ها:

Proteus mirabilis ، urinary tract infections ، FimH ، MrpH ، FliC