Crosslinked natural hydrogels for drug delivery systems

سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 41

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شناسه ملی سند علمی:

JR_JRCC-4-11_006

تاریخ نمایه سازی: 6 اسفند 1402

چکیده مقاله:

Hydrogels made from a variety of materials may be used as a novel technology in regenerative medicine in the biomedical field. Hydrogels may be made using both chemical and physical processes, depending on the source material. Size, elastic modulus, swelling, and degradation rate are only a few of the many physical parameters that may be used to define hydrogels in experiments. Hydrogels made from natural polymers have been the focus of our review. Due to their remarkable biocompatibility and nontoxicity, simple gelation, and functionalization, hydrogels derived from natural polymers have received extensive attention in recent decades. As a result, natural polymer hydrogels are considered excellent biomaterials that have great potential in the biomedical field. Because carriers play such a large role in determining how far and how fast drugs reach their intended recipients, the need for intelligent drug delivery systems (DDSs) is on the rise. An outstanding goal of this study is to examine the impact that various crosslinking process parameters have on the drug delivery mechanism.Hydrogels made from a variety of materials may be used as a novel technology in regenerative medicine in the biomedical field. Hydrogels may be made using both chemical and physical processes, depending on the source material. Size, elastic modulus, swelling, and degradation rate are only a few of the many physical parameters that may be used to define hydrogels in experiments. Hydrogels made from natural polymers have been the focus of our review. Due to their remarkable biocompatibility and nontoxicity, simple gelation, and functionalization, hydrogels derived from natural polymers have received extensive attention in recent decades. As a result, natural polymer hydrogels are considered excellent biomaterials that have great potential in the biomedical field. Because carriers play such a large role in determining how far and how fast drugs reach their intended recipients, the need for intelligent drug delivery systems (DDSs) is on the rise. An outstanding goal of this study is to examine the impact that various crosslinking process parameters have on the drug delivery mechanism.

نویسندگان

Akram Noori Tahneh

Department of Pharmaceutical Chemistry, Pharmaceutical Science Branch, Islamic Azad University, Tehran, Iran

Bahareh Dashtipour

Department of Chemistry, Alzahra University, Tehran, Iran

Alireza Ghofrani

Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran

Somayeh Keramati Nejad

Clinical Research Development Unit of Razi Hospital, Birjand University of Medical Science, Birjand, Iran